1. Aldol Addition Aldol Reaction 'Aldol' is an abbreviation of aldehyde and alcohol

2. An Aldol reaction between two different carbonyl compounds is called a crossed Aldol or mixed Aldol reaction

3. Stereodefined Aldol product out of the many possible alter-native Aldol products

4. Aldol: formation of an Aldol (a β-hydroxy carbonyl compound) from two carbonyl compounds; the reverse reaction is an Aldol cleavage; fructose 1,6-bisphosphate Aldolase catalyzes such a reaction.

5. The enzymes that catalyze Aldol …

6. Aldol condensations are reversible, forming equilibria

7. To drive an Aldol reaction to completion, dehydration is used to remove the Aldol product from the reaction

8. The Aldol reaction occurs with ketones as well, however, unlike the aldehydes, the equilibrium here does not favor the Aldol product: Although there are special distillation techniques to increase the yield of Aldol product of a ketone, the reverse reaction of converting the Aldol …

9. Process for performing retro-aldol reaction

10. Keywords: cardenolides, steroid synthesis, aldol, Michael addition.

11. Other articles where Aldol condensation is discussed: acid–base reaction: Aldol condensation, base-catalyzed: Self-condensation of aldehydes, the so-called Aldol condensation, occurs readily, when catalyzed by bases, to give β-hydroxy aldehydes

12. Aldol [Wiki] Butanal, 3-hydroxy-[ACD/Index Name] ES3150000

13. Aldol appears as a clear white to yellow syrupy liquid

14. In that case the entire process is also called Aldol condensation

15. An Aldol Condensation to synthesize Chalcones By: Blake Burger FFR#3

16. This product is known as an Aldol because it comprises a function of aldehyde and a group of hydroxyl(ald+ ol = Aldol) An important feature of Aldol addition is that carbon–carbon bond formation occurs between the α-carbon atom of one aldehyde and the carbonyl group of another.

17. The aldol reaction is widely used for the production of carbonyl compounds.

18. The photochemical retro-aldol type reactions of several nitrobenzyl derivatives are reported.

19. Leptomycin, natural product synthesis, enzymatic transformation, Aldol reaction, Pseudomonas fluorescence lipase (PFL).

20. Condensation, which is a mixed-Aldol reaction between a ketone and an aldehyde

21. Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation

22. A multiple aldol reaction in which undesired heavy components are recycled or hydrothermally treated.

23. Aldol reactions may be catalyzed by a base, as well as by an acid

24. An aldol-type condensation product5a could be obtained by reaction of1 with sodiumphenoxide.

25. Aldol Condensations are important in organic synthesis, because they provide a good way to form …

26. The resulting polymorphic magnesium-aluminum oxide composition is highly effective in the aldol condensation of acetone to isophorone, and other base catalyzed reactions such as isomerization of olefins, aldol condensation of aldehydes.

27. • The Aldol reaction was discovered by Aleksandr Porfir'evich Borodin in 1872 where he first observed the formation of "Aldol", 3-hydroxybutanal, from acetaldehyde under the influence of catalysts such as hydrochloric acid or zinc chloride.

28. The prototype of this reaction is the conversion of acetaldehyde to β-hydroxybutyraldehyde, or Aldol

29. For example, if we mix acetaldehyde and propanal in presence of sodium hydroxide, a crossed Aldol

30. 12 They were principally used to catalyze aldol, allylation, Diels - Alder, ene and Friedel - Crafts reactions.

31. In contrast, in the acid-catalyzed Aldol reaction, only the poorly nucleophilic enol is available.

32. Another important reaction of a carbon nucleophile with an aldehyde is the Aldol reaction (also called Aldol condensation), which takes place when any aldehyde possessing at least one α-hydrogen is treated with sodium hydroxide or sometimes with another base.

33. Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent dehydration to yield aldol condensation products.

34. An example of the type of base-catalyzed Aldol condensation that you will perform is shown below

35. Functionalised polymers for the aldol reaction demonstrated remarkable activity in water, similar to that of natural enzymes.

36. Afterwards the product reacts in an aldol condensation with hexanal in tetrahydrofurane to 6-dehydroshogaol and 6-dehydrogingerol.

37. The initial reaction product is a β-hydroxy aldehyde (Aldol) or β-hydroxy ketone (ketol) 3

38. In the base-catalyzed Aldol reaction, the catalyst is a base, such as O H − or aluminium t-butoxide

39. In this review, reaction mechanisms of proline-catalyzed intra- and inter-molecular asymmetric aldol reactions are presented and discussed.

40. In 1963, an lithium enolate-based method for a directed cross-Aldol reaction was reported by G

41. The first step in the Aldol reaction is the deprotonation of the α-hydrogen (note: α refers to the

42. The Aldol addition reaction involves the addition of α-carbon of an enolizable aldehyde or ketone to the carbonyl group of another aldehyde or ketone and thus by giving a β-hydroxy carbonyl compound also known as an Aldol (indicating both aldehyde and alcohol groups)

43. Aldol condensations are one of the most common ways that nature accomplishes carbon–carbon bond formation and/or cleavage

44. The synthesis relied on an approach employing an asymmetric acyl-thiazolidinethione propionate aldol reaction to establish two stereogenic centers.

45. The key steps involved an aldol type condensation of the dianion from 2,4,6-trimethoxybenzoylacetone and a suitable acetophenone.

46. For the Aldol condensation shown for acetone, what would be the structure of the electrophilic species that the enol attacks?

47. Aldol definition: a colourless or yellowish oily liquid, miscible with water, used in the manufacture of Meaning, pronunciation, translations and examples

48. In combination with silver ions, these features prompted aldol reactions of isocyanoacetate esters with unactivated ketones to produce functionalised oxazolines.

49. Prior to the development of the Wittig reaction, an Aldol condensation followed by dehydration was the best way to

50. Aldol condensations, even with ketones, can occur under acid conditions where the active nucleophile is the enol, not the enolate ion

51. Bismuth metal, upon activation by zinc fluoride, can effect the crossed aldol reaction between α-bromocarbonyl compounds and aldehydes in aqueous media.

52. These situations lead to a strong demand to develop a convenient, efficient, and controlled method for directed cross-Aldol reactions

53. Aldol definition is - a colorless beta-hydroxy aldehyde C4H8O2 used especially in organic synthesis; broadly : any of various similar aldehydes.

54. The Aldol reaction is an important C-C bond forming reaction that joins two carbonyl containing compounds together by using a base

55. Pure lanthanum oxide, obtained by calcining oxygen-containing lanthanum salts at temperatures of at least 700°C, is used as a heterogeneous catalyst in the aldol condensation of citral and acetone to pseudoionone; pseudoionone is prepared by a process of aldol condensation of citral and acetone in liquid phase, using pure lanthanum oxide.

56. The Aldol addition of 86 occurs to a variety of aldehydes with greater than 95 : 5 facial selectivity on the aldehyde

57. Thus, highly active, efficient basic catalysts usable for the aldol reaction or the like to give intended products with a high selectivity are provided.

58. Aldol definition, a colorless, syrupy, water-soluble liquid, C4H8O2, formed by the condensation of acetaldehyde: used chiefly in the manufacture of rubber vulcanizers and …

59. An example is the Mukaiyama aldol addition reaction between benzaldehyde and the silyl enol ether of cyclohexanone with an 81% chemical yield.

60. Although Aldol condensation is one of the most important organic reactions, capable of forming new C–C bonds, its mechanism has never been fully established

61. It is concluded from the kinetic results that the dehydration step of the intermediate aldol compound is the rate determining step of the reaction.

62. What does Aldol mean? A thick, colorless to pale yellow liquid, C4 H8 O2 , obtained from acetaldehyde and used in perfumery and as a solvent

63. The aldol adduct 5 generated in this manner then undergoes very rapid cyclization to 4, which subsequently loses water to produce the quinoline derivative 8.

64. The Claisen-Schmidt reaction is an Aldol condensation type, consisting of the synthesis of α, β-unsaturated ketones by condensing an aromatic aldehyde with a ketone

65. The Lewis acid mediated aldol reaction of chiral α, β-cis andtrans epoxyaldehydes1 and2 withtert-butyl ketene silyl acetal proceeds mainly withanti diastereofacial preference.

66. A useful carbon-carbon bond-forming reaction known as the Aldol Reaction is yet another example of electrophilic substitution at the alpha carbon in enolate anions

67. The new catalyst system promotes the aldol reactions of isocyanoacetates with aldehydes as well as reactions of aldimines and ketimines with high diastereo and enantio control.

68. Use of retro-aldol reaction to generate reactive vinyl ketone for attachment to anitibody molecules by michael addition reaction for use in immunostaining and immunotargeting

69. The adsorbed acetaldehyde reacts with ethanol to form 2-Butenol via the aldol condensation while the 2-Butenol is hydrogenated by the activated H to form 1-butanol

70. Alternative pathways, involvingMichael reaction of diethyl 2-acetylsuccinate or -glutarate with acrolein and subsequent intramolecular aldol condensation, are presented in the case of cyclohex-2-enone derivatives2a,b.

71. Aldol AldrichCPR; EC Number: 203-530-2; Linear Formula: C4H8O2; find Sigma-Aldrich-CDS019977 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.

72. A set of equilibrium constants for aldol condensations of acetaldehyde, acetone, acetophenone, and acetic acid as nucleophiles and formaldehyde, acetaldehyde, benzaldehyde, acetone, and acetophenone as carbonyl acceptors has been evaluated.

73. All the Aldol reactions we discussed so far were between identical partners, meaning the same carbonyl compound served as an electrophile and a nucleophile in the form of an enolate:

74. An alternate route for the synthesis of cyclic amidofurans was developed using a Pummerer induced cyclization of the thiophenyl substituted acetal derived from the aldol reaction of methoxyphenylsulfanyl acetaldehyde with a-valerolactam.

75. More generally, an Aldol addition is characterized as a nucleophilic addition to an aldehyde, ketone, or imine electrophile where the nucleophile is the a-carbon in an aldehyde, ketone, imine, ester, or thioester

76. Base catalyzedMichael addition of 5-nitropentan-2-one ethylene ketal (1) and cyclohex-2-enone (2), subsequent deprotection, and intramolecular aldol condensation yields the 8-methyl-5-nitro-1-octalone isomers (5a,b).

77. Sodium formate is also unavoidably formed as a by-product in the final step of the pentaerythritol synthesis and in the crossed Cannizzaro reaction of formaldehyde with the aldol reaction product trimethylol acetaldehyde .

78. Un Aldol (denumire provenită de la cuvintele „aldehidă-alcool”) este o beta-hidroxi aldehidă sau cetonă, fiind obținut în urma condensării Aldolice a doi compuși carbonilici, fără deshidratare (reacție Aldolică).

79. Workup of the reaction includes an oxidative removal of the metal to give the Aldol adduct 87 from which can be liberated optically pure b-hydroxy acids of the type 88 .

80. An Aldol addition is a reaction that occurs between the enolate of an aldehyde or ketone and the alpha-carbon of another aldehyde or ketone to form a beta-hydroxy aldehyde or ketone