1. In the presence of tolbutamide liver slices from fasting rats formed less acetoacetic acid and β-hydroxybutyric acid.

2. In eleven patients with diabetes insipidus centralis the effect of chlorpropamide, tolbutamide, glybenclamide, glycodiazin, hydrochlorothiazide and vasopressin was investigated.

3. Females ranged from 0.6–15.0 mμg/ml (mean 5.1 mμg/ml) and 15 acromegalics from 8.0–103.0mμg/ml (mean 31.2 mμg/ml). — During a rapid tolbutamide tolerance test, serum HGH rose between 2.5- and 82-fold over the fasting levels within 10 to 70 minutes following the glucose nadir.

4. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant medication on sildenafil pharmacokinetics when grouped as CYP#C# inhibitors (such as tolbutamide, warfarin, phenytoin), CYP#D# inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP# metabolism (such as rifampicin, barbiturates