1. These toxins are the sole cause of fatal human Amanita intoxications.

2. In addition, three acute non-fatal intoxications associated with ADB-CHMINACA were reported by one Member State.

3. A special focus is put on Antidotes and important aspects of diagnosis and therapy of acute intoxications

4. Aconitum napellus (monkshood) intoxications are well known in Asia because the plant is often used in traditional medicines.

5. In case of coma, intoxications in relation to urea cycle disorder, organic aciduria or maple syrup urine disease should be considered.

6. Disorders of energy metabolism and “endogenous intoxications” (syndromes leading to hyperammonemia, hyperhomocysteinemia, porphyria, aminoacidopathy, and organic aciduria) represent the two major categories of IEMs.

7. While for many overdoses and intoxications the treatment involves supportive care and treatment of the sequelae there are specific Antidotes available for a variety of substances.