1. Abasic, กรุงเทพมหานคร

2. What is the definition of Abasic? What is the meaning of Abasic? How do you use Abasic in a sentence? What are synonyms for Abasic?

3. Pharmaceutical compounds comprising abasic oligonucleotides

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5. Inverted Abasic Site (dSpacer Abasic furan) is primarily used to block the ends of the oligo

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7. Synonyms for Abasic in Free Thesaurus

8. Abasic \ ə- ˈbā- sik , - zik \ adjective

9. Definition of Abasic in the Definitions.net dictionary

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12. Chemiluminescent DNA Abasic (AP) Site Assay APPLICATION DNA Abasic sites are a type of DNA damage generated by reactive oxygen species (oxidative damage)

13. The Abasic site exhibits poor stability, especially in basic medium

14. Bio-Synthesis offers dSpacer Abasic oligonucleotide modification at various scales

15. 1. Abasic - of or relating to abasia (inability to walk)

16. DSpacer is commonly used to mimic an Abasic site in

17. Abasic sites are the common lesions that arise in cellular DNA

18. Abstract Abasic sites are one of the most common DNA lesions

19. Abasic (not comparable) (medicine) Of, pertaining to or caused by abasia

20. DSpacer, similar to C3 spacer, is commonly used to mimic an Abasic …

21. Abasic - (O-0207) --> Skip to the beginning of the images gallery

22. DSpacer is commonly used to mimic an Abasic site in an oligonucleotide

23. MetaComCo also developed ABasiC for the Amiga which was initially provided with Amigas.

24. It can also be used for structural studies in comparison to Abasic furan

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26. Information and translations of Abasic in the most comprehensive dictionary definitions resource on the web.

27. Abasic (AP) sites are one of the most common DNA lesions that block replicative polymerases

28. A general method for the photochemical generation of ribose Abasic sites within RNA oligonucleotides is reported

29. DNA Abasic sites have led to an important mechanistic under-standing of DNA damage repair (1)

30. All known Abasic site repair mechanisms operate only when the damage is in double-stranded DNA

31. This method allows quantification of the number of DNA Abasic sites per 105 base pairs of …

32. Abasic sites in DNA are prevalent as both naturally forming defects and as synthetic inclusions for biosensing applications

33. The Abasic residue displaced by DNA repair synthesis must be removed before ligation can complete the BER reaction

34. DSpacer (Abasic furan) is a tetrahydrofuran derivative, in which a methylene group occupies the 1 position of 2-deoxyribose

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36. Abasic sites are highly mutagenic lesions in DNA that arise as intermediates in the excision repair of modified bases

37. DSpacer (Abasic furan) is a tetrahydrofuran derivative, in which a methylene group occupies the 1 position of 2'-deoxyribose

38. Irradiation of the modified RNA at 350 nm efficiently produced ribose Abasic sites at specific sites within RNA sequences

39. The Abasic residue (dR) exists predominantly in the cyclic form and the structure is shown (1) in Figure 1

40. Here we report the effect of an Abasic site on the rate and yield of charge transport through temperature-controlled

41. Here, we uncover RNA Abasic sites in yeast and human cells, which are not as rare as assumed; there are …

42. Endogenous DNA Abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae EMBO J

43. Also provided are conjugates between abasic oligonucleotides and various immunostimulatory nucleic acids, including CpG oligonucleotides, as well as methods of use thereof.

44. DSpacer, also known as Abasic furan, is a tetrahydrofuaran derivative containing a methylene group occupied in the 1 position of 2’-deoxyribose

45. A key feature of biological sources of strand breaks is associated nucleotide damage, including base loss (Abasic or apurinic/apyrimidinic (AP) sites) 2

46. In contrast, Abasic sites in the RNA are not known except for the site in ribosomal RNA induced by the plant poison ricin

47. This degradation reaction leads to chain scission at the Abasic site with formation of a 5'-phosphate segment and a 3'-modified segment.

48. In DNA, Abasic sites are generated by hydrolysis of the glycosidic linkage to the nucleotide base, leaving just the sugar-phosphate backbone at that

49. Naturejobs - All Jobs In this study, we present X-ray structures of a DNA polymerase caught while incorporating a nucleotide opposite an Abasic site

50. This results in generation of one or more abasic sites which can interact with and/or into where the intercalator molecule can be inserted.

51. DNA Abasic sites The dSpacer (1,2'-Dideoxyribose) modification (Figure 1A) can be used to insert a single base space into a DNA oligonucleotide sequence

52. Abasic sites are generated both spontaneously by the hydrolysis of glycosidic bonds ( 3, 4) and enzymatically by N-glycosidases that remove misincorporated bases ( 5)

53. Abasic sites represent the most frequent DNA lesions in the genome that have high mutagenic potential and lead to mutations commonly found in human cancers

54. The present invention relates to primers for PCR amplification comprising abasic parts within the primer sequences and a method for PCR amplification using the same.

55. An AP site (apurinic/apyrimidinic site), also known as an Abasic site, is a location in DNA that has neither a purine nor a pyrimidine base

56. Formed as a result of DNA damage, as well as a key intermediate during the base excision repair pathway, Abasic sites are frequent DNA lesions that …

57. Although these lesions are devoid of the genetic information, adenine is most efficiently inserted when Abasic sites are bypassed by DNA polymerases, a phenomenon termed A‐rule.

58. Missing bases or Abasic sites in the DNA were discovered in the 1960s and spawned the field of DNA repair and advanced our understanding of cancer and aging

59. Disclosed are polymeric compounds which are useful as prodrugs, comprising a chain of monomeric nucleosides, nucleoside analogs or abasic nucleosides, wherein at least one of the nucleosides or nucleoside analogs or a heterocyclic derivative thereof is pharmaceutically active and the nucleosides, nucleoside analogs or abasic nucleosides are linked by a phosphodiester group, a phosphorothioate group or an H-, alkyl or alkenyl phosphonate group.

60. Abasic sites are thought to be the most frequently occurring cellular DNA damage and are generated spontaneously or as the result of chemical or radiation damage to DNA

61. In contrast to the wealth of information that exists on the effects of Abasic sites on DNA polymerases, very little is known about how these lesions interact with RNA polymerases.

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63. The primers for PCR amplification of the present invention contain abasic parts not having specific coding information in their nucleotide sequences, so that they can amplify different templates having mutated sites at the same time.

64. In contrast, only a few studies of Abasic sites in the RNA have been reported, such as those in ribosomal RNA generated by ricin and loss of bulky bases that are susceptible to depurination (2, 3)

65. Biaryl derivatives that consist of one DNA‐intercalating unit and a sterically demanding component exhibit a specific behavior towards Abasic site‐containing DNA (AP‐DNA) as determined by thermal DNA denaturation experiments, spectrometric titrations and CD spectroscopic analysis.

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67. Evaluating steady-state damages in specific tissues of the rat, Nakamura and Swenberg indicated that the number of abasic sites varied from about 50,000 per cell in liver, kidney and lung to about 200,000 per cell in the brain.

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69. A method for characterising nucleic acid molecules comprises the steps of: i) introducing a modified base which is a substrate for a DNA glycosylase into a DNA molecule; ii) excising the modified base by means of said DNA glycosylase so as to generate an abasic site; iii) cleaving the DNA at the abasic site so as to generate an upstream DNA fragment that can be extended; and iv) incubating the extendible upstream fragment in the presence of an enzyme, for example a polymerase or a ligase, allowing for extension thereof and a template nucleic acid and analysing the resultant fragment(s).

70. More precisely, the present invention relates to primers capable of amplifying different templates and having abasic parts complementary to mutated site or polymorphic site of template DNA and a method for PCR amplification comprising the steps of mixing the composition for PCR amplification comprising the primers with nucleic acid template; and performing PCR with the mixture.

71. A method of detecting a methylated cytosine of the invention comprises the steps of: hybridizing an oligonucleotide capable of hybridizing to a region containing a cytosine which is expected to be methylated in a sample DNA and having an abasic site at a position complementary to the cytosine to the sample DNA; oxidizing a methylated cytosine by reacting an oxidizing agent with the hybridized sample DNA formed in the previous step when a methylated cytosine is present therein; and detecting the oxidized methylated cytosine.