dedifferentiated in English

verb
1
(of a cell or tissue) undergo a reversal of differentiation and lose specialized characteristics.
For example, they found that the proliferating cells dedifferentiated , meaning they temporarily lost the characteristics of mature heart muscle cells and reverted to a more fetal type of proliferating cell.

Use "dedifferentiated" in a sentence

Below are sample sentences containing the word "dedifferentiated" from the English Dictionary. We can refer to these sentence patterns for sentences in case of finding sample sentences with the word "dedifferentiated", or refer to the context using the word "dedifferentiated" in the English Dictionary.

1. Dedifferentiated Acinic cell carcinoma is a highly malignant, newly recognized parotid malignancy

2. Dedifferentiated Acinic cell carcinoma of the salivary gland is an uncommon variant of Acinic cell carcinoma, characterized by the coexistence of both an usual low-grade Acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course

3. Blastema is a tissue that is formed after tissue injury in such organisms and is composed of progenitor cells or dedifferentiated cells that differentiate into various cell types during regeneration

4. It is strongly believed that the cells in the Blastema originate from dedifferentiated local tissue at the amputation site; however, adult stem cells (e.g., muscle satellite cells and possibly also the periosteum and dermis) [35-39] also contribute to the formation of the Blastema, though the number of these endogenous cells may be insufficient