1. Disadvantages: Some allergic reactions and a few cases of toxic shock syndrome reported.

2. 11 There are several candidates for the toxin that might cause toxic shock syndrome.

3. Allergic reactions and more severe adverse effects such as toxic shock syndrome have been reported.

4. The calcium sugar acid salt reduces the production of Toxic Shock Syndrome Toxin-1 (TSST-1) by S. aureus.

5. Abcs Case Definition Invasive group A streptococcal disease: isolation of group A Streptococcus from a normally sterile site or from a wound culture accompanied by necrotizing fasciitis or streptococcal toxic shock syndrome in a resident of a surveillance area in 2018.