Use "tophi" in a sentence

1. We report on 6 cases of intradermal tophi and review the literature on this disorder, which includes a rare case of combined psoriasis and intradermal tophi.

2. Clinical manifestations of gouty arthropathy are usually acute inflammatory arthritis, bursitis and accumulation of urate crystals in the form of tophi.

3. Long-standing elevated uric acid levels (hyperuricemia) may result in other symptoms, including hard, painless deposits of uric acid crystals known as tophi.

4. These tophi occur in 30% of those who are untreated for five years, often in the helix of the ear, over the olecranon processes, or on the Achilles tendons.