1. When sensitivities are known and the isolate is confirmed as resistant to both INH and RMP, five drugs should be chosen in the following order (based on known sensitivities): an aminoglycoside (e.g., amikacin, kanamycin) or polypeptide antibiotic (e.g., capreomycin) PZA EMB a fluoroquinolones: moxifloxacin is preferred (ciprofloxacin should no longer be used); rifabutin cycloserine a thioamide: prothionamide or ethionamide PAS a macrolide: e.g., clarithromycin linezolid high-dose INH (if low-level resistance) interferon-γ thioridazine meropenem and clavulanic acid Drugs are placed nearer the top of the list because they are more effective and less toxic; drugs are placed nearer the bottom of the list because they are less effective or more toxic, or more difficult to obtain.