1. Human data show that tacrolimus is able to cross the placenta

2. Elimination When administered intravenously, tacrolimus has been shown to have a low clearance rate

3. The changes were caused by high systemic exposure of rodents resulting from high transdermal absorption of tacrolimus

4. Elimination ng lo When administered intravenously, tacrolimus has been shown to have a low clearance rate

5. Interestingly, rats administered Tacrolimus acutely after TBI showed significantly fewer non-Convulsive seizures than untreated rats, but a …

6. Cyclosporin A, still up for discussion! Beneficial effect of tacrolimus … Cyclosporin A, still up for discussion! Gastroenterology

7. Drugs such as ketotifen, doxepin, H2-blockers, glucocorticoids, leukotriene receptor antagonists, COX-2-inhibitors, antimalarials, dapsone, sulfasalazine, antibiotics, acyclovir, nifedipine, danazol, terbutaline, warfarin, histaglobin, cyclosporine, tacrolimus, methotrexate, cyclophosphamide and intravenous immunoglobulin are reviewed as well as measures such as plasmapheresis, phototherapy, diet and psychosomatic treatment.

8. A variety of innovations, such as techniques for early detection of Epstein-Barr (EBV) and CMV infections, bone marrow augmentation, the adjunct use of the interleukin-# antagonist daclizumab, lower initial tacrolimus doses with target trough levels of # to # ng/ml, and most recently allograft irradiation were considered to have contributed to improved results in this indication over time (Abu-Elmagd et al., Ann Surg