1. Key words: long chain base, fatty acid, sphingomyelin, guinea pig, Harderian gland.

2. 9 Sphingomyelin is found in large amounts in brain and nerve tissue.

3. The body needs Choline to synthesize phosphatidylCholine and sphingomyelin, two major phospholipids vital for cell membranes.

4. Choline is a quaternary ammonium salt and a precursor of phospholipids, such as sphingomyelin and phosphatidylCholine (lecithin), which are used to build the cell membrane during the cell proliferation process, the event that is augmented in malignant tissues.