Use "sixfold" in a sentence

1. When smokers were given ammonium chloride, kidney excretion of nicotine increased sixfold.

2. Reports have indicated a sixfold increase in applicants for jobs advertising a telework possibility.

3. The sixfold or greater relative risk of suicide implied by the unsubstantiated suicide death tolls is also demonstrated to be incompatible with the findings of epidemiologic studies of mortality risk among Vietnam veterans.

4. The construction of infrastructure serving the summit, by Darkin experts' estimates, would aid the economic development of the Russian Far East and would see more than a sixfold increase of the Gross Regional Product of Primorsky Krai by 2020.