1. Synonyms for Austerer include sterner, severer, stricter, harsher, colder, harder, grimmer, flintier, graver and seriouser

2. As expected, the expression of IL23 caused chronic paw swelling and Arthroclisis of knee in injected mice and these symptoms were much severer in SOCS3 knockdown mice than those observed in wild-type animals (Figure 2A).