1. Serum sickness occurs when the immune system has a delayed response to medications or Antiserums

2. Serum sickness, brachial plexus neuropathy, encephalomyelitis and transverse myelitis have rarely been reported in association with tetanus vaccination.

3. To prevent serum sickness, it is often best to use an antitoxin obtained from the same species (e.g. use human antitoxin to treat humans).

4. Antivenoms can also cause serum sickness, a delayed (type III hypersensitivity) reaction characterized by fever, urticaria, lymphadenopathy, and polyarthralgias days to weeks after treatment.

5. Antivenins can also cause serum sickness, a delayed (type III hypersensitivity) reaction characterized by fever, urticaria, lymphadenopathy, and polyarthralgias days to weeks after treatment

6. Snake Antivenins poses a life-threatening risk, both remain far from ideal -- triggering a generalized and sometimes severe immunological reaction called serum sickness in about 75 percent of recipients.

7. Arteritis may occur in a number of diseases, including syphilis, tuberculosis, pancreatic disease, serum sickness (a reaction against a foreign protein), and lupus erythematosus (a systemic disease that has also been attributed to some form of immune reaction).

8. Clinical manifestations may include one or more of the following: fever, rash or severe dermatologic reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome); vasculitis, arthralgia, myalgia, serum sickness; allergic pneumonitis, interstitial nephritis; acute renal insufficiency or failure; hepatitis, jaundice, acute hepatic necrosis or failure; anemia, including hemolytic and aplastic; thrombocytopenia, including thrombotic thrombocytopenic purpura; leukopenia; agranulocytosis; pancytopenia; and/or other hematologic abnormalities.