1. Idiopathic thrombocytopenic purpura.

2. Post-transfusion purpura

3. The “Purpura” snail

4. Thrombotic thrombocytopenic purpura?

5. Schönlein described purpura rheumatica (Schönlein's disease) an allergic non-thrombopenic purpura rash that became known as Henoch–Schönlein purpura, though now known as IgA vasculitis.

6. Senile purpura, also called Actinic purpura, is a benign skin condition that commonly affects older adults

7. Hematologic System: isolated thrombocytopenic purpura

8. Anaemia, neutropenia Thrombocytopenia, lymphadenopathy, lymphopenia Aplastic anaemia* Pure red cell aplasia, idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura

9. Ultrastructural examination revealed a microthrombotic purpura.

10. urticaria, psoriasis, ecchymosis and increased bruising, purpura

11. As a result, the Purpura population dropped.

12. Blood and lymphatic system disorders Thrombocytopenia, thrombocytopenic purpura

13. Pancytopenia, bone marrow depression, leukopenia, thrombocytopenia, purpura, anaemia

14. However, thrombotic thrombocytopenic purpura can be reversed with Apheresis

15. Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy.

16. Post-transfusion purpura (PTP) is an uncommon adverse event.

17. Immune thrombocytopenic purpura is the commonest acquired haematological pathology.

18. Cases of interstitial lung disease, thrombocytopenia, idiopathic thrombocytopenic purpura and allergic purpura following immunization were evaluated, but were not considered to represent new safety issues.

19. Blood and Lymphatic System Disorders: leukopenia, lymphopenia, neutropenic sepsis, purpura

20. Bruising on the back of the hands and arms (called actinic purpura or solar purpura) occurs because skin there is often sun-damaged and thin

21. Another name for old age skin Bruising is senile purpura

22. Models of thrombotic thrombocytopenic purpura and methods of use thereof

23. The present invention also relates to the treatment of immune thrombocytopenic purpura.

24. Symptoms of the disease are conjunctivitis, purpura, petechiae and occasionally sepsis.

25. The Henoch-Schönlein-syndrome, or anaphylactoid purpura, is usually a childhood disease.

26. Fourteen of these cases were afflicted with immune thrombocytopenic purpura (ITP, M.

27. The symptoms primarily described in Morbus Moschcowitz included thrombocytopenic purpura and hemolytic anemia.

28. It was not clear whether Mr. Purpura made a similar complaint through his counsel.

29. 11 Background : Henoch - Schonlein purpura nephritis ( HSPN ) is a common secondary glomerulonephritis in children.

30. Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder characterised by shortened platelet survival.

31. In particular, palpable purpura, hypocomplementemia, cryoglobulinemia and lymphoma are associated with increased mortality.

32. Purpura: This type of Bruising typically involves small bleeding that occurs under the skin

33. Illness may be complicated by haemolytic uraemic syndrome (HUS) or thrombotic thrombocytopenic purpura (TTP).

34. Thrombotic Thrombocytopaenic Purpura (TTP) TTP has been reported with the use of other thienopyridines

35. As the incidence of purpura haemorrhagica is very low, its occurrence cannot be ruled out completely

36. In other cases of DIC not associated with purpura fulminans, bleeding is the dominant clinical feature.

37. This case report demonstrates the various clinical symptoms of Purpura Henoch Schoenlein and its clinical course.

38. delayed untoward effects after transfusion, such as hemolysis, acute GvHD, post-transfusion purpura, ALT increase, hemochromatosis, etc;

39. Between 1971 and 1985, 46 patients (aged 13–69 years) with thrombocytopenic purpura (FTP) underwent splenectomy.

40. The main clinical manifestations are a palpable purpura predominantly of the lower extremities, arthritis, arthralgia and abdominal pain.

41. Two patients with post-transfusion thrombocytopenic purpura are described, the first cases recognized in Austria and Germany.

42. In particular, therapeutic agents to treat IgA Nephropathy, Dermatitis herpetiformis (DH), and Henoch-Schoenlein purpura (HS) are disclosed.

43. Henoch–Schönlein purpura (HSP) is characterized by vasculitic involvement of small-sized vessels and results in multisystem manifestations.

44. This bleeding can take the form of pinpoint dots (petechiae), larger, flat areas (purpura), or broad areas of Bruising (ecchymosis).

45. The composition of the infiltrate supports the hypothesis that purpura pigmentosa progressiva is an allergic reaction of the delayed type.

46. There are three common types of Bruises that can occur based on the severity of an injury: contusions, hematomas and purpura

47. TRALI (51), severe allergic (5), acute hemolytic reaction (3), bacterial contamination (3), post-transfusion purpura (2), TACO (1) and hypotensive reaction (1).

48. Granulocytopenia, leukopenia or agranulocytosis 72(3) Pancytopenia (or pancytopenic picture†) 15(6) Thrombotic thrombocytopenic purpura 7 Disseminated intravascular coagulation 1(1) Thrombocytopenic purpura 1 Thrombocytopenia 12(2) Thrombocytopenia with granulocytopenia 5 Thrombocytopenia with anemia 3 Granulocytopenia with anemia 5 Anemia 6 Bleeding with or without anemia 9(3)‡ Lymphopenia 2

49. 20 sera withγM-globulin increases in Waldenström's macroglobulinemia, chronic lymphadenosis (1 case) and purpura hyperglobulinemica (1 case) served to demonstrate the electrophoretic changes after dissociation of the macroglobulin by cysteamine.

50. Alfalfa is an herbal supplement which can be used as treatment for asthma, arthritis, diabetes, excessive production of urine (diuresis), high cholesterol, indigestion, and excessive bruising or bleeding (thrombocytopenic purpura).

51. Adverse transfusion event Major allergic/ anaphylactic reaction TRALI Circulatory overload Acute hemolytic transfusion reactione Bacterial contamination ABO incompatibility Hypotensive transfusion reaction Post-transfusion purpura Delayed hemolytic transfusion reaction Other Total a b

52. The coloring matter was evidently obtained from the Murex and Purpura mollusks, piles of emptied shells of the Murex trunculus having been found along the shore of Tyre and in the vicinity of Sidon.

53. = Immunkomplexerkrankung mit Aberrantem IgA = häufigste Glomerulonephritis AE: - Infektion der oberen Atemwege (postinfektiöse Manifestation nach 1-3d) - Renale Maniefstation der Purpura-Schönlein-Hennoch SYMP: - Mikrohämaturie (50%) - Nephrotisch - Nephritisch - Akutes/ …

54. The exact cause of Schonlein-Henoch Purpura is not fully understood, although research suggests that it may be an autoimmune disease or, in some rare cases, an extreme allergic reaction to certain offending substances (e.g., foods or drugs).

55. Actinic purpura results from sun-induced damage to the connective tissue of the dermis (deeper layers of the skin) combined with the fact that the blood vessels become thinner and more fragile and collagen decreases with increasing age.

56. Results of Investigation & Conclusion3 Severe Allergic Reactions, e.g., Anaphylactic/Anaphylactoid - Signs and Symptoms ABO Incompatibility Acute Haemolytic Reactions Viral Infections (type) Bacterial Infections Other Infections Transfusion Related Graft-Versus-Host Disease (TR-GVHD) TRALI Post Transfusion Purpura Unknown4 Others (specify)3 Severity :

57. Contrast with a Vascular Skin Reaction (Erythema Multiforme, Urticaria) which does blanch; Compare with Purpura or Ecchymosis which like a Contusion does not blanch; Color (unreliable as an indicator of injury timing) Days 0-2: Swelling and tenderness; Days 2-5: Red, blue or purple coloration

58. Being u sed in chronic diarrhea, purpura, phobias, obsessions, compulsions, excessive anxiety, insomnia, chronic cough (due to TB), vomiting blood, bleeding in the uterus not during menses and metrostaxis (s mall but continuous haemorrhage of the uterine mucous membrane), Apostaxis （slightly bleeding), hemoptysis (coughing up blood

59. Table 4 Type of adverse transfusion events by relationship to transfusion Relationship to transfusion Definite Adverse transfusion event Major allergic /anaphylactic reaction TRALI Circulatory overload Acute hemolytic transfusion reaction Bacterial contamination ABO incompatibility Hypotensive transfusion reaction Post-transfusion purpura Delayed hemolytic transfusion reaction Viral infectionc Otherd Total a b

60. Bilateral symmetrical reactions of vasomotoric origin, related to dermatoma, are observed in cases of reflex-erythema, cerebral disease (intoxication, brain tumor, injury of the brain-stem, encephalitis), in a great number of allergic skin reactions (drug rush, eczema, peliosis rheumatica, purpura, measles, scarlatina), in leukemia, liver cirrhosis, virus infections, etc.

61. Table 9 Type of adverse transfusion events by relationship to transfusion, 2004-2005 Relationship to transfusion Type of adverse transfusion event Severe/Allergic/Anaphylactoid ABO incompatibility Hemolytic reaction: acute Hemolytic reaction: delayed TACO TRALI Possible TRALI TAD Bacterial contamination TRAIN Hypotensive reaction Post-transfusion purpura Other2 Unknown Total 1 2

62. Besides the typical lupus forms, nonspecific skin lesions are also observed such as dermal mucinosis, acneiform skin lesions, different variants of livedo, necrotizing vasculitis with ulcers, purpura, urticaria vasculitis, neutrophilic dermatosis, hyperpigmentation, hair and nail changes as well as overlap syndromes with erythema multiforme, scleroderma, Sjögren syndrome, Raynaud phenomenon, lichen planus, bullous pemphigoid und psoriasis.

63. Clinical manifestations may include one or more of the following: fever, rash or severe dermatologic reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome); vasculitis, arthralgia, myalgia, serum sickness; allergic pneumonitis, interstitial nephritis; acute renal insufficiency or failure; hepatitis, jaundice, acute hepatic necrosis or failure; anemia, including hemolytic and aplastic; thrombocytopenia, including thrombotic thrombocytopenic purpura; leukopenia; agranulocytosis; pancytopenia; and/or other hematologic abnormalities.

64. Neurologic complications: delirium and hallucinations related to alcohol or contaminated heroin or cocaine, or benzodiazepine use; seizures related to overdoses, cocaine-induced vasospasm, abscess, HIV-related infection, embolic or thrombotic stroke, meningitis, subdural hematoma, and alcohol withdrawal; traumatic and atraumatic mononeuropathies; Bell's palsy; infectious neurologic complications (meningitis, brain abscess, subdural and epidural abscesses, mycotic aneurysms). Immunologic abnormalities: hypergammaglobulinemia; thrombocytopenic purpura.

65. Thus the compound of general formula [1] is useful in the treatment and prevention of autoimmune diseases fundamentally caused by immunopathy or abnormally accelerated cell adhesion, for example, chronic rheumatoid arthritis, systemic lupus erythematosus, sclerema, mixed connective tissue disease, polyarteritis nodosa, polymyositis/dermatomyositis, Sjögren's syndrome, Behcet's disease, multiple sclerosis, autoimmune diabetes, Hashimoto's disease, psoriasis, primary myxedema, pernicious anemia, serious adynamia, ulcerative colitis, chronic active hepatitis, autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura.

66. Physical Signs of Nutritional Deficiency Disorders System Sign General appearance Skin and hair Reduced weight for height Pallor Edema Nasolabial seborrhea Dermatitis Photosensitivity dermatitis Acrodermatitis Follicular hyperkeratosis (sandpaper-like) Depigmented skin Purpura Scrotal or vulval dermatitis Alopecia Depigmented, dull hair Decreased Poor adaptation to dark Poor color discrimination Bitot’s spots, xerophthalmia, keratomalacia Conjunctive pallor Fundal capillary microaneurysms Angular stomatitis Cheilosis Bleeding gums Atrophic papillae Smooth tongue Red tongue (glossitis) Parotid swelling Caries Anosmia Hypogeusia Goiter Heart failure Hypogonadism Costochondral beading Subperiosteal hemorrhage Cranial bossing Wide fontanel Epiphyseal enlargement Craniotabes Tender bones Tender calves Spoon-shaped nails (koilonychia) Transverse nail lines