1. The acellular pertussis components (pertussis toxin

2. Pertussis is a highly contagious, acute infectious bacterial disease, caused by Bordetella pertussis.

3. Synonym(s): Bordetella pertussis

4. 208 Pertussis vaccine (acellular, component, adsorbed) ..5.3-3407 Pertussis vaccine (acellular, co-purified, adsorbed) ...........

5. Against diphtheria, pertussis and tetanus

6. The acellular pertussis antigen preferably comprises pertussis holotoxin (PT) and filamentous haemagglutinin (FHA) and, optionally, pertactin.

7. All adults should be vaccinated once only against pertussis with the combined Td and acellular pertussis (Tdap) vaccine.

8. DTaP : Diphtheria , tetanus , and acellular pertussis vaccine

9. * Tdap : Tetanus , diphtheria , and pertussis booster

10. with acellular pertussis vaccine. As of September 2004, all provinces/territories had implemented universal adolescent acellular pertussis programs with Tdap.

11. The fimbrial agglutinogen preparation may be used to prepare acellular pertussis vaccines with other pertussis antigens, including pertussis toxin or toxoid thereof, the 69 kDa protein and filamentous haemagglutonin and other Bordetella antigens.

12. Babies with pertussis make a " whooping " sound .

13. Diphtheria toxoid# Tetanus toxoid# Bordetella pertussis antigens

14. Encephalopathy within # days of administration of a previous dose of any vaccine containing pertussis antigens (whole cell or acellular pertussis vaccines

15. B. pertussis and occasionally B. parapertussis cause pertussis or whooping cough in humans, and some B. parapertussis strains can colonise sheep.

16. Thus, Acellular pertussis vaccine is reserved for the 4th and …

17. The lack of a monovalent acellular pertussis vaccine limits the choices.

18. OBJECTIVES: To assess the efficacy and safety of Acellular pertussis vaccines in children.

19. tho Diphtheria toxoid# Tetanus toxoid# Inactivated Bordetella pertussis # Hepatitis B surface antigen (rDNA

20. Cautions for Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Contraindications

21. Acellular pertussis vaccines (containing purified or recombinant Bordetella pertussis antigens) were developed in the hope that they would be as effective but less reactogenic than the whole-cell vaccines

22. There are two formulations of acellular pertussis vaccine, the infant/pediatric formulation (aP) and the adolescent/adult formulation (ap). The latter contains a lower concentration of pertussis antigens than the former.

23. Currently, all jurisdictions in Canada fund administration of acellular pertussis vaccine to adolescents.

24. However , you should discuss the risks of the pertussis vaccine with your doctor .

25. Most of these side effects result from the pertussis component of the vaccine .

26. Shared primer pcr combined with hybridisation for the detection of bordetella pertussis and b parapertussis

27. The medical term for the disease is pertussis - the " P " in the DTaP vaccine .

28. Three months prior to admission, he had had a culture-confirmed case of pertussis.

29. Background NACI recommends the administration of a single dose of the adolescent/adult formulation of the acellular pertussis vaccine to pre-adolescents, adolescents, and adults who have not received a dose of acellular pertussis vaccine.

30. Major communicable and non-communicable diseases are diphtheria, pertussis, tetanus, hepatitis B & human influenza B.

31. These six childhood diseases are measles, poliomyelitis, tuberculosis, diphtheria, pertussis (whooping cough), and neonatal tetanus.

32. Ushuaia suffered several epidemics, including typhus, pertussis, and measles, that much reduced the native population.

33. A high proportion is missing the recommended booster doses against diphtheria, tetanus, pertussis and polio.

34. Vaccination against pertussis is especially important for those in direct contact with young infants or patients .

35. Despite serious safety concerns, people take Coltsfoot for lung problems such as bronchitis, asthma, and whooping cough (pertussis)

36. In the United States, an acellular pertussis vaccine was recently licensed for the primary infant immunization series.

37. Diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, hepatitis B (recombinant) and Haemophilus influenzae type b conjugate vaccine, adjuvanted

38. The objective of this study was to assess the local and systemic tolerability of two batches of the Biken acellular pertussis (Pa) vaccine following administration of a single vaccine dose to adults with or without a history of prior pertussis immunization.

39. However, data indicate that protection against pertussis may be waning at # years of age with this #-# months schedule

40. Immediate allergic reactions can occur, including allergic shock after the vaccination, generally in combination with diphteria and pertussis.

41. If you are younger than 65 , one of these doses should also include protection against pertussis ( whooping cough ) .

42. Acellular pertussis vaccine (aP) with three or more antigens prevents around 85% of typical whooping cough cases in children

43. • Afebrile convulsions have not been shown to be caused by pertussis vaccine and are not a contraindication to immunization.

44. Bordet-Gengou potato blood agar - glycerin-potato agar with 25% of blood, used for the isolation of Bordetella pertussis.

45. The first three doses of acellular pertussis vaccine are the most critical in reducing infant mortality and hospitalization rates.

46. Guidelines for the production and control of Acellular pertussis component of monovalent and combined vaccines were adopted in 1996

47. BOOSTRIX (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed) is a noninfectious, sterile, vaccine for intramuscular administration

48. Studies with conjugate meningococcal vaccine and with adult/adolescent formulations of tetanus, diphtheria and acellular pertussis vaccines (Tdap) are under way.

49. • Chickenpox Diphtheria Hepatitis B Invasive Hib Disease Measles Mumps Acute Flaccid Paralysis Pertussis Poliomyelitis Rubella Congenital Rubella Syndrome Tetanus

50. Jules Bordet and Octave Gengou isolated Bordetella pertussis, a causative agent for whooping cough, in Paris more than 100 years …

51. * pertussis - a respiratory illness with cold symptoms that progress to severe coughing ( the " whooping " sound occurs when the child breathes in deeply after a severe coughing bout ) ; serious complications of pertussis can occur in children under 1 year of age , and those under 6 months old are especially susceptible .

52. PERTUSSIS IN PERSPECTIVE Epidemiological Situation in Canada Dr. Adwoa Bentsi-Enchill, Ottawa, Ontario Follow-up of the Recommendations from the Consensus Conference on Pertussis Dr. Gaston DeSerres, Ste-Foy, Quebec Acellular Vaccines: New Developments and Efficacy Studies Dr. Scott Halperin, Halifax, Nova Scotia SESSION IV:

53. Today, immunization programs have been generally effective in controlling many diseases —tetanus, polio, diphtheria, and pertussis (whooping cough), to name a few.

54. This is the basis for advance inoculation with a vaccine (toxoid) against polio, mumps, rubella (measles), diphtheria-tetanus-pertussis, and typhoid fever.

55. Teens and adults with a persistent cough may not realize they have pertussis , and may pass it to vulnerable infants .

56. B. pertussis was discovered in 1906 by Jules Bordet and Octave Gengou, who also developed the first serology and vaccine.

57. Background: Whole-cell diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) were introduced to children in Guinea-Bissau in 1981

58. Acellular (chemically detoxified or recombinant) pertussis vaccine formulation appears to cause fewer adverse reactions than whole-cell vaccine in most studies

59. Pertussis toxin activity, determined by clustering of Chinese hamster ovary cells, was found in the allantoic fluid following inoculation of virulent bacteria.

60. A U.S. study has also shown increased redness and pain with the fifth dose of a variety of acellular pertussis vaccines(26).

61. - pertussis - a respiratory illness with cold symptoms that progress to severe coughing ( the " whooping " sound occurs when the child breathes in deeply after a severe coughing bout ) ; serious complications of pertussis can occur in children under 1 year of age , and those under 6 months old are especially susceptible .

62. Selective literature review of occupationally acquired aerogene infections like SARS-coronavirus, influenza virus, parainfluenza virus, RSV, adenovirus, tuberculosis as well as pertussis.

63. Use of the DTaP vaccine has virtually eliminated diphtheria and tetanus in childhood and has markedly reduced the number of pertussis cases .

64. It has higher or similar efficacy to the previously-used whole cell pertussis vaccine, however the efficacy of the Acellular vaccine declines faster

65. HEXAVAC suspension for injection in pre-filled syringe Diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, hepatitis B (recombinant) and Haemophilus influenzae type b conjugate vaccine, adjuvanted

66. The infant improved after treatment with clarithromycin and was administered the first dose of diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP).

67. The Tdap Cocoon Program was created to help implement the Cocooning strategy in Connecticut, to help protect infants from pertussis Tdap Vaccination - Referral Sites

68. If you have a history of coma , or seizures within a week following a tetanus vaccine that contains pertussis components , get Td vaccines only .

69. Discussion: The purpose of our report is to remind physicians of the rare possibility of a shock-like reaction after DT- or DTP immunization in infancy, which has also been observed in association with the use of the new acellular pertussis component vaccines – although less frequently than after conventional whole cell pertussis component vaccines.

70. Of Blunting is also not clear and espe cially difficult to establish for pertussis, in the absence of an agreed immunological correlate of protection [12]

71. Tetanus, diphtheria, Acellular pertussis vaccine (Tdap) Generic Name: tetanus, diphtheria, Acellular pertussis vaccine (Tdap) (TET a nus, dif THEER ee a, and ay SEL yoo ler per TUS iss) Brand Name: Adacel (Tdap), Boostrix (Tdap), Boostrix (obsolete2) (obsolete) Dosage Forms: intramuscular suspension (5 units-2 units-15.5 mcg/0.5 mL; 5 units-2.5 units-18.5 mcg/0.5 mL)

72. The vaccines are made up of tetanus , diphtheria , and pertussis toxins that have been made nontoxic but they still have the ability to create an immune response .

73. The suboptimal protective effect of acellular pertussis vaccines and the rapid decline of immunity even after booster vaccinations justify the search for new and more effective vaccines.

74. Safety of childhood vaccines was recently increased further by adopting inactivated polio and acellular pertussis vaccines and is closely monitored by provincial and federal programs, some quite innovative.

75. Immunization coverage Recommendation 3 Achieve and maintain age-appropriate immunization coverage with acellular pertussis vaccine in 95% of infants by 3 months of age (first dose) by 2010.

76. The strategy of protecting infants from pertussis by vaccinating those in close contact with them is known as “Cocooning.” ACIP has recommended Cocooning with Tdap vaccine since 2005

77. Recommendations to assure the quality, safety and efficacy of Acellular Pertussis Vaccines, Annex 4, Technical Report Series 979 pdf, 939kb Replacement of Annex 2 of WHO TRS 878

78. Acellular pertussis vaccines comprise purified toxin or toxoid thereof, filamentous haemagglutinin, pertactin and fimbrial agglutinogens formulated to confer protection to at least 70 % of members of an at-risk population.

79. The duration of protection afforded by acellular pertussis vaccines is not known, but the data seem to indicate that protection does not decline during the first 4 years of follow-up.

80. In Jules Bordet …the bacterium, now known as Bordetella pertussis, that is responsible for whooping cough, Bordet became professor of bacteriology at the Free University of Brussels (1907–35)