1. Very rare: haemolytic anaemia, pancytopenia, agranulocytosis

2. Pancytopenia, bone marrow depression, leukopenia, thrombocytopenia, purpura, anaemia

3. agranulocytosis granulocytopenia pancytopenia haemolytic anaemia thrombocytopenia leukopenia erythrocytopenia

4. Cases of agranulocytosis, thrombocytopenia, leukopenia, aplastic anaemia, pancytopenia and leucocytosis have been reported

5. There have been postmarketing reports of pancytopenia and aplastic anaemia, some of which had fatal outcomes (see section

6. Decreases in haemoglobin and haematocrit, thrombocytopenia, leucopenia/neutropenia, and cases of agranulocytosis or pancytopenia, have been reported very rarely

7. We report on a 66 year old patient originating from Greece and living in Germany with a prosthetic mitral valve because of a combined vitium following juvenile rheumatic fever. The patient fell ill with acute fever, splenomegaly, and pancytopenia.

8. Aplastic anemia (AA) is identified as an immune-mediated bone marrow failure, characterized by “Anhematopoiesis” and peripheral blood pancytopenia [].Hematopoietic stem cell transplantation (HSCT) is curative in a large majority of patients with severe AA (SAA) younger than 40 years old.

9. Granulocytopenia, leukopenia or agranulocytosis 72(3) Pancytopenia (or pancytopenic picture†) 15(6) Thrombotic thrombocytopenic purpura 7 Disseminated intravascular coagulation 1(1) Thrombocytopenic purpura 1 Thrombocytopenia 12(2) Thrombocytopenia with granulocytopenia 5 Thrombocytopenia with anemia 3 Granulocytopenia with anemia 5 Anemia 6 Bleeding with or without anemia 9(3)‡ Lymphopenia 2

10. Clinical manifestations may include one or more of the following: fever, rash or severe dermatologic reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome); vasculitis, arthralgia, myalgia, serum sickness; allergic pneumonitis, interstitial nephritis; acute renal insufficiency or failure; hepatitis, jaundice, acute hepatic necrosis or failure; anemia, including hemolytic and aplastic; thrombocytopenia, including thrombotic thrombocytopenic purpura; leukopenia; agranulocytosis; pancytopenia; and/or other hematologic abnormalities.