1. Dysmenorrhea, hypermenorrhea, primary and secondary amenorrhea and oligomenorrhea require investigation and an adequate diagnostic pathway.

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3. 39 hirsute women with oligomenorrhea or secondary amenorrhea with elevated excretion of 17-ketosteroids were treated for 2–21 months with 6-dehydro-16-methylenehydrocortisone (St C 407) and the influence of this synthetic cortisol derivative on the function of the adrenals was tested. In 30 cases, normal excretion of 17-ketosteroids occurred when dosages of 5–10 mg/day St C 407 were given. In 9 women higher dosages to a maximum of 30 mg/day were necessary.