1. The dark Leydig-cells possess a tubule-formed, fine-meshed, tightly packed, agranular, endoplasmatic reticulum.

2. The testes of coho and pink salmon apparently contain both interstitial (Leydig) cells and lobule boundary cells.

3. Here, we explore how Aconitine affects androgen synthesis and metabolism in rat immature Leydig cells in vitro.

4. Aconitine might have reproductive toxicity and the effects of Aconitine on androgen synthesis in Leydig cells remain unclear

5. Statistically significant increases in the incidence of benign testicular interstitial (Leydig 's) cell adenomas were observed in all dosage groups

6. In the rat, the only drug-related lesions were Leydig cell hyperplasia and testicular adenoma resulting from the hypoprolactinaemic effect of ropinirole

7. The Sertoli cells contain an agranular reticulum that is less developed than that of the Leydig cells, and rarely show mitochondria with tubular cristae.

8. This type of Leydig cell adenoma is compared with the bilateral tumour-like enlargement of the testis, which is ocassionally observed in congenital adrenogenital syndrome.

9. As was seen in the oral study in rats discussed previously, there was a significant increase in the incidence of interstitial testicular Leydig cell adenomas in this study.

10. Pijnloze, scrotale massa Risico factor beiden testis! : (enkelzijdige!) Cryptorchidisme (niet indalen) Primary germ cell (95%): 40% seminoom, 40% mixed, non-seminoom Primary non-germ cell (Leydig, Sertoli) Secondary Metastase

11. Rats chronically exposed to PFOA resulted in increased incidences of liver adenomas, Leydig cell hyperplasia/adenomas and pancreatic acinar cell tumours (PACT) in male Sprague-Dawley rats (Biegel et al., 2001).

12. Hormonal changes (primary testicular deficiency, decreased amplitude of hypothalamic GnRH secretion peaks), morphological and histological testicular changes (arteriolar sclerosis, Leydig cell and Sertoli cell degeneration, rarefaction of germ cells, thickening of the testicular tunica albuginea) related to physiological ageing are relatively well documented.

13. The occurrence of nodular hilar cell proliferations of the ovary in adrenogenital syndrome (AGS), as observed in a newborn girl, should be interpreted as the female counterpart to occasional testicular Leydig cell hyperplasia described in AGS by Landing (1951) and Odunjo (1962).

14. Administration of miglustat to male and female Sprague-Dawley rats by oral gavage for # years at dose levels of #, # and # mg/kg/day resulted in an increased incidence of testicular interstitial cell (Leydig cell) hyperplasia and adenomas in male rats at all dose levels

15. - ST degeneration, reduced number of Leydig cells and mature sperm within the lumen, sperm breakages, spermatolysis, Androgone fusion and/or pycnosis (≥2.5 mg/kg); Formula: TiO 2 Size: ~ 5.5 nm SA: 174.8 m 2 /g HS: 208–330 nm Zeta potential: 9.28 mV: 1.25, 2.5, 5 mg/kg/day 6 months: Intragastric: CD-1 Mice Testis Epididymis Sperm