1. Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (hypokalaemia, hyponatraemia, and hypochloremic alkalosis

2. Pseudo-Bartter Syndrome is defined by a hypochloremic-hypokaliemic metabolic alkalosis but without primary tubular renal defects.

3. Treatment with loop diuretics might result in hypochloremic metabolic acidosis nowadays termed chloride-depletion alkalosis for pathophysiological reasons.

4. The hypochloremic nephrosis and adrenocortical insufficiency were regarded as consequences of severe dehydration and sodium chloride loss caused by diarrhea, ascites and edema.