1. Generally, men with unexplained hypergonadotropic Azoospermia need to undergo a chromosomal evaluation

2. Premature ovarian failure is characterized by amenorrhea and hypergonadotropic hypogonadism before 40 years of age.

3. Leading symptom is primary, hypergonadotropic amenorrhea with normal body height and usually without associated anomalies, with the exception of the Turner syndrome and other rare syndromes.

4. The ovary ofperimenopausal patients was much more sensitive to cytotoxic drugs; following a short time chemotherapy hypergonadotropic amenorrhea invariably developed and the ovary seemed to be again the prime site of action.Postmenopausal patients continued to have physiologically high LH and FSH plasma concentrations and low plasma levels of prolactin and 17β-estradiol under cytotoxic treatment.