1. 704-550-2165 Arbusterol 6186613 heterolytic

2. Keywords: acid–base behaviour, protonated species, decomposition, homolytic dissociation, heterolytic dissociation.

3. For instance, when an acid dissolves in water, a covalent bond between an electronegative atom and a hydrogen atom is broken by heterolytic fission, which gives a proton (H+) and a negative ion.

4. It is possible that either BOT3 or Bot1 would oxidize either the 10- or the 15-hydroxy group to the hydroperoxide derivative, which would then undergo heterolytic fragmentation to give the dialdehyde botrydial (PubMed:27529428)