1. In relation to the extent of infiltration a surprising degree of destruction in the connective tissue is caused by acrodermatitis atrophicans Herxheimer.

2. Don't confuse Aggravations from coming off drugs to Aggravations being produced when you clean the body up from Candida die off or Herxheimer reactions; they're entirely different

3. They most often affect the skin, nervous system, joints and heart. Cutaneous pseudolymphomas, erythema chronicum migrans of Afzelius, acrodermatitis chronica atrophicans of Pick-Herxheimer, meningo-radiculitis and various arthropathies are the most commonly encountered diseases.

4. Discussion: For diagnosis of borreliosis the most frequently observed dermatological manifestations like erythema migrans, lymphocytosis cutis and acrodermatitis chronica atrophicans Herxheimer, as well as associated dermatosis like lichen sclerosis et atrophicus, granuloma anulare and morphea are reviewed.