1. Pepsin also undergoes feedback inhibition; a product of protein digestion slows down the reaction by inhibiting pepsin.

2. Negative feedback inhibition would therefore explain the greater sensitivity of amylase secretion for the detection of pancreatic disease.

3. There are conflicting reports as to whether negative feedback inhibition exists in humans and whether it is mediated by cholecystokinin.

4. Upon binding, intracellular signaling and gene expression regulations are altered, leading to the production of other Cytokines, surface receptors, or feedback inhibition

5. It therefore blocks the binding of oestradiol and thus prevents negative feedback inhibition of FSH secretion; the action of Clomifene results in greater stimulation of ovarian follicles via increased FSH when a woman is being treated with Clomifene then