1. The sheer futility of it all exasperates her.

2. It exasperates me to hear comments like that.

3. Synonyms for Aggravates include annoys, irritates, exasperates, irks, nettles, vexes, peeves, piques, provokes and riles

4. Synonyms for Annoys include harasses, aggravates, antagonises, antagonizes, bugs, exasperates, galls, gets, goads and irks