1. According to the present invention, there are provided ethacrynic acid, a transglutaminase inhibitor comprising active components of a pharmaceutically acceptable salt of ethacrynic acid and a transglutaminase inhibition method.

2. Ethacrynic acid-containing composition and method for prevention and treatment of transglutaminase-related diseases

3. The K/Na ratio in the epithelial cells decreased after ethacrynic acid injection (60 mg/kg i.V.).