1. Objective:To develop the estriol suppository and verify its effects.

2. Objective:To study examining stability method of estriol suppository .

3. Conclusion:The method was simple, it was suitable for examining stability of estriol suppository .

4. 15 In the case of estriol, the placenta utilizes a dehydroepiandrosterone precursor made in the adrenal glands of the fetus.

5. After the second month of pregnancy, estriol levels steadily increase as the placenta takes over estrogen production. 3

6. A defect in either the fetus or the placenta will be reflected by a decrease in estriol production. 3

7. A review of activated sludge plant performance found estrogen removal rates varied considerably but averaged 78% for estrone, 91% for estradiol, and 76% for ethinylestradiol (estriol effluent concentrations are between those of estrone and estradiol, but estriol is a much less potent endocrine disruptor to fish).

8. The latter com pound crosses into the placenta which takes over with the necessary enzymes to complete the synthesis of estriol.