1. Pure red cell Aplasia (PRCA) is a rare disorder that presents with anemia secondary to the failure of erythropoiesis

2. [1019][1] In vivo models that recapitulate human erythropoiesis with persistence of Circulating red blood cells (RBCs) have remained elusive.

3. These mice exhibited enhanced human erythropoiesis and Circulating huRBC survival and could recapitulate SCD pathology when reconstituted with SCD-derived HSCs

4. The lymphatic tissues were damaged by all these drugs, the granulopoiesis by all substances exept by amethopterin and prednisolone, the erythropoiesis, however, only by TEM, actinomycin C, vinblastine and by large doses of amethopterin.