1. Psymberin, also known as irciniastatin A, is a cytotoxin derived from sea sponges.

2. M. ulcerans grows optimally on routine mycobacteriologic media at 33 °C and elaborates a necrotizing immunosuppressive cytotoxin (mycolactone).

3. Up to five Cytotoxins (cytotoxin 1, 2, 4, 5, and 11) have been isolated and strongly implicated in the cytotoxicity of N