1. 21 The pathophysiology of cluster headache is not established.

2. Observed every year on 21 March, Cluster Headache Awareness Day is on the day of the equinox - "Cluster headache has a strong Biorhythmicity, therefore cluster headache patients know this date from which on daytime in Europe will be longer than nighttime which is a relief for at least some sufferers".

3. Objective: To evaluate olanzapine as a cluster headache Abortive agent in an open-label trial

4. There are very few recognized Abortive therapies for cluster headache and fewer for patients who have contraindications to vasoconstrictive drugs.

5. A Capsaicin 0.025% cream (Zostrix, Rodlen Laboratories) applied daily for 7 days has been used to treat acute cluster headache attacks

6. De-Afferentation neuropathic pain; cluster headache; migraine; A more extensive list of the causes of facial pain includes the following: dental problems (e.g

7. The Medical Journal of Australia called this “a major advance in therapy,” adding: “The advent of the triptans . . . was to migraine and cluster headache almost the equivalent of penicillin to bacterial infection!”

8. Such compositions may be used to treatment of pain, severe pain, chronic pain, chemotherapy induced pain, epilepsy, glaucoma, arthritis, tooth aches, inflammation, musculoskeletal pain, sciatica, radiculopathy pain, migraine, neuropathic pain, post herpetic neuralgia, neuralgia pain, multiple sclerosis, multiple sclerosis, restless legs syndrome (RLS), cluster headache, depression, fibromyalgia, amyotrophic lateral sclerosis (ALS), convulsions, partial seizures, mood-stabilizing agent and bipolar disorder.