1. Assess the differences between classes of Biologic disease-modifying antirheumatic drug (DMARD) therapy

2. Herb: Cocklebur Latin name: Xanthium strumarium Synonyms: Xanthium canadense Family: Compositae Medicinal use of Cocklebur: The leaves and root are anodyne, antirheumatic, appetizer, diaphoretic, diuretic, emollient, laxative and sedative

3. The invention further relates to compounds that are prodrugs of adenosine receptor agonists, and to their use as therapeutic compounds, in particular as analgesic or anti-inflammatory compounds, or as disease modifying antirheumatic drugs (DMARDs), and to methods of preventing, treating or ameliorating pain or inflammation using these compounds.