1. The known clinical manifestations are imbecility, obesity, growth retardation, hypogonadism and hypogenitalism, acromicria, dolichocephalus, an adult-type of diabetes mellitus and a history of myatonia.

2. The symptom-complex is generally characterized — apart from adipositas, psychic changes, and intellectual defects — by obstructions in the development of the extremities, thus indicating a delay of the structural change (acromicria, clinodactylia, genua valga, metatarsus varus).