telomerase in English
Human cells have an additional barrier to unfettered replication - most lack the chromosome repair enzyme called telomerase that rat cells possess.
Use "telomerase" in a sentence
1. 2 Objective To detect telomerase activity in patients with mycosis fungoides(MF )and study the role of telomerase in the tumorigenesis of MF.
2. Patients with Dyskeratosis congenita have defective telomerase function.
3. Telomerase inhibitors (i.e., Azidothymidine) can represent promising antitumor agents, although showing high toxicity when administered alone
4. Project scientists made major advances on the value of telomerase and telosome components as biomarkers for cancer diagnosis.
5. A particular enzyme called telomerase can restore the telomere to full length, thus allowing the cell to keep dividing.
6. It's because human genetics has taught us that when it comes to our telomerase, we humans live on a knife edge.
7. Acridine derivatives are known to exhibit an array of bioactivities including antimicrobial, anticancer, antibiotic, anti-AchE, antileukemia, antimalarial, antipsychotic, antidepressant, antidimentia, telomerase inhibition, and many others
8. What about replacing the body’s stem cells (cells that provide for the regeneration of body tissue) with stem cells that have been “immortalized” with active telomerase?
9. ‘Fortunately, the Amitotic division and high telomerase activity in the large macronucleus allowed Paramecium to be transformed by microinjection of DNA fragments and a method for cloning genes by complementation was developed.’
10. ‘Fortunately, the Amitotic division and high telomerase activity in the large macronucleus allowed Paramecium to be transformed by microinjection of DNA fragments and a method for cloning genes by complementation was developed.’
11. In most cells this enzyme is repressed and inactive, but active telomerase has been successfully inserted into certain cells, making them grow and divide far beyond the normal number of times.
12. So even if you could buy that Costco-sized bottle of telomerase, and there are many websites marketing such dubious products, the problem is you could nudge up your risks of cancers.
13. Acyclic nucleoside analogs such as acyclovir, ganciclovir, penciclovir and the corresponding pro-drugs, i.e., valacyclovir, valganciclovir and famciclovir, respectively have been identified as inhibitors or antagonists of both telomerase (encoded by TERT) and reverse transcriptase encoded by L-1 (LINE-1) RT, and as useful for treating or preventing cancers induced or mediated by the two enzymes.
14. Azidothymidine is an anticancer drug that not only competitively decreases telomerase activity in tumor cells via active Anabolite azidothymidine triphosphate (AZTTP) and arrests the tumor cells by favoring apoptosis or inducing senescence (24), (25), but also through decreasing Bc1-2 expression and concentration in tumor cells lowers the resistance of the cells to apoptosis and increases their …