tachyphylaxis in English

noun
1
rapidly diminishing response to successive doses of a drug, rendering it less effective. The effect is common with drugs acting on the nervous system.
Trebling doses of histamine diphosphate were chosen instead of the usual doubling dose because of the half-life of lidocaine, the number of challenges, and the need to minimize possible tachyphylaxis of the histamine effect.

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1. To prevent tachyphylaxis, a topical steroid is often prescribed to be used on a week on, week off routine.