oligonucleotide in English
Probes are typically fairly short sequences of DNA nucleotides, called oligonucleotides , made synthetically.
Use "oligonucleotide" in a sentence
1. We have developed a second-generation Antisense oligonucleotide (ISIS 25302) specific for murine TNF-alpha and have evaluated this oligonucleotide in …
2. Antisense oligonucleotide-based therapeutics involves downregulation of gene expression
3. The adaptor may be a cholesterol-linked DNA adapter oligonucleotide.
4. Bio-Synthesis offers dSpacer Abasic oligonucleotide modification at various scales
5. DSpacer is commonly used to mimic an Abasic site in an oligonucleotide
6. Adaptor A short synthetic oligonucleotide which creates an internal restriction endonuclease site
7. 13 The double-stranded oligonucleotide was then purified by polyacrylamide gel electrophoresis.
8. Avidity is pioneering a new class of oligonucleotide-based therapies called AOCs designed to overcome the current limitations of oligonucleotide therapies in order to treat a wide range of serious diseases.
9. Avidity Biosciences is pioneering a new class of oligonucleotide-based therapies called AOCs designed to overcome the current limitations of oligonucleotide-based therapies in order to treat a wide range of serious diseases.
10. The Azides are offered in 25 and 100 µmole packs for convenient oligonucleotide labeling
11. The A-form geometry imparts properties to the oligonucleotide that modulate binding affinity and nuclease resistance.
12. 2 The world's lingering,the end is still no match for the forget the bitter oligonucleotide soup.
13. An oligonucleotide containing a synthetic nucleic acid such as BNA is preferred because of the high stability thereof.
14. This invention discloses high-affinity oligonucleotide ligands to the thermostable $i(Taq) polymerase and $i(Tth) polymerase.
15. The incorporation of these modified phosphoroamidite analogues in oligonucleotide sequences can simulate the lesions occurring on the DNA strands.
16. DNA Abasic sites The dSpacer (1,2'-Dideoxyribose) modification (Figure 1A) can be used to insert a single base space into a DNA oligonucleotide sequence
17. aptus: fit) is a short single stranded DNA or RNA oligonucleotide, able to bind a target molecule specifically and with high affinity accordingly to its three dimensional structure.
18. There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of Antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in medicine
19. Markers for each component were developed using decamer oligonucleotide primers 14).Hairy root cultures of Astragalus have been established and produced cycloartane saponins 15).Saponin is the major chemical constituent type in the Astragalus …
20. The present invention relates to highly specific oligonucleotide primers and probes useful in a rapid and specific method for detecting the presence of Group B Streptococcal (GBS) or Streptococcus agalactiae infection in a biological sample.
21. N-Myc, with its restricted expression in non-fetal tissues, is a therapeutic target to treat rhabdomyosarcomas, and blocking gene transcription using Antigene oligonucleotide strategies has therapeutic potential in the treatment of cancer and other diseases that …
22. To test this hypothesis, 34 human specimens obtained during carotid endarterectomy or bypass procedures were examined by use of specific oligonucleotide primers for Porphyromonas gingivalis, Prevotella intermedia, Actinobacillus actinomycetemcomitans and Bacteroides forsythus in polymerase chain reaction (PCR) assays.
23. We have shown that the splicing of a refractory exon, SMN2 exon 7, could be increased in fibroblasts derived from patients with spinal muscular atrophy by using Bifunctional targeted oligonucleotide enhancers of splicing (TOES) oligonucleotides that anneal to the exon and …
24. Antisenses against WT1 which comprise oligonucleotide derivatives containing 1 or more sugar-modified nucleotide analog units represented by the following general formula (2) wherein B represents a pyrimidine nucleic acid base, a purine nucleic acid base or an analog thereof.
25. An oligonucleotide encoding a gene which is capable of regulating the synthesis of abscisic acid and encoding an amino acid sequence consisting of from M at the 1-position to I at the 164-position of the amino acids in the sequence represented by SEQ ID NO:2 in Sequence Listing, or oligonucleotides containing an oligonucleotide encoding an amino acid sequence derived from the above-described amino acid sequence by deletion, substitution or addition of one or several amino acids; products of these oligonucleotides; and vectors and plants containing these oligonucleotides.
26. The first to enter in clinic has been Vitravene an Antisense oligonucleotide for the treatment of cytomegalovirus (CMV) infection and more recently, research on aptamers have led to the marketing of anti-vascular endothelial growth factor (VEGF) inhibitor (Macugen) for the treatment of age-related macular degeneration (AMD).
27. Bacterial colonies were pooled and harvested, chromosomal DNA extracted and analysed by negative selection PCR for the presence of individual mutant DNA by using oligonucleotide primers specific for Tn10d-cat (blainv and Blarev) in combination with genome specific primers , which were designed to bind 100–1000 bp adjacent to the corresponding
28. A method of detecting a methylated cytosine of the invention comprises the steps of: hybridizing an oligonucleotide capable of hybridizing to a region containing a cytosine which is expected to be methylated in a sample DNA and having an abasic site at a position complementary to the cytosine to the sample DNA; oxidizing a methylated cytosine by reacting an oxidizing agent with the hybridized sample DNA formed in the previous step when a methylated cytosine is present therein; and detecting the oxidized methylated cytosine.
29. The conjugated medicinal agent of the present invention has the following formula (I): P-(S)x-Gal-GA-R, wherein in the P-(S)x-moiety, P is a peptide residue of a human serum glycoprotein and S is a sugar residue of a human serum glycoprotein; Gal is galactose residue; GA is glutaraldehyde residue; x is an integer equal to or greater than 1; and R is a medicinal component selected from the group consisting of interferon, acyclovir sodium, ribavirin, vidarabine, zidovudine, suramin, anti-sense oligonucleotide, ribozyme, leucovorin calcium, sodium-meglumine diatrizoate, gadolinium-DTPA, glutathione (GSH), prostaglandins, ?