glucuronide in English

noun

type of glycoside (Chemistry)

Use "glucuronide" in a sentence

Below are sample sentences containing the word "glucuronide" from the English Dictionary. We can refer to these sentence patterns for sentences in case of finding sample sentences with the word "glucuronide", or refer to the context using the word "glucuronide" in the English Dictionary.

1. The major urinary metabolites are alpha-OH Alprazolam glucuronide and …

2. In spite of the chemical variation, the glucuronide still possesses high affinity to opioid receptors and the polarity of the glucuronide does obviously not exclude penetration of the blood-brain barrier.

3. The Acyl glucuronide also inhibits the proliferation of isolated human mononuclear leukocytes 127

4. The urinary metabolites of phenol that have been identified in mammals, including humans, are phenyl glucuronide, phenyl sulphate and the corresponding conjugates of hydroquinone - 4-hydroxyphenyl glucuronide and 4-hydroxyphenyl sulphate (Capel et al.,., 1972; Hiser et al.,., 1994; Hughes and Hall, 1995).

5. Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin Adductions in diclofenac patients J Pharmacol Exp Ther

6. It is believed that "fast acetylators" metabolize aniline predominantly by N-acetylation (to acetanilide), followed by aromatic hydroxylation (to N-acetyl-p-aminophenol), and subsequent conjugation to glucuronide or sulphate (DECOS, 1989).

7. The mechanism of a previously described rise in the excretion rate of aldosterone-18-glucuronide under the influence of norethisterone-acetate was further investigated in 10 male volunteers.

8. Laropiprant Laropiprant is metabolised primarily via acyl glucuronidation, with a smaller component of oxidative metabolism, followed by excretion of the glucuronide into faeces (via bile) and urine

9. About 3% and 9% of the dose of moxifloxacin, as well as about 2% and 4.5% of its glucuronide metabolite are removed by continuous ambulatory peritoneal dialysis and hemodialysis, respectively."

10. Patients with chronic hepatitis and with liver cirrhosis showed a decrease in the glucuronide and an increase in free N-acetyl-p-aminophenol after a dose of 1200 mg acetanilide.

11. 23 Acetaminophen is mainly metabolized in the liver by first-order kinetics and its metabolism of comprised of 3 pathways: conjugation with glucuronide, conjugation with sulfate, and oxidation through the cytochrome P450 enzyme pathway, mainly CYP2E1, to produce a reactive

12. However, the Acyl glucuronide has a 12‐fold higher IC 50 for IMPDH inhibition than mycophenolic acid and a 5‐ to 10‐fold lower plasma concentration, and is therefore unlikely to contribute significantly to inhibition of IMPDH in patients 123.

13. The compound has the predicted properties: when included in the standard membrane filter test for the analysis of water, indoxyl-β-D-glucuronide allows specific detection of E. coli through the formation of blue colonies that are the result of rapid conversion of the liberated aglycone to indigo.

14. 12 patients with chronic hepatitis and 12 patients with liver cirrhosis as proved by laparascopy and histological examination received peroral doses of 800 or 1200 mg acetanilide. 12 healthy persons of the same age served as a controll. 2, 6 and 24 hrs after giving the dose free N-acetyl-p-aminophenol and its glucuronide were determined in the serum and in 24 hrs urine.